The Green Terror (5-4, 2-1 CC) finished with a 32-1 advantage in the shot column and a 15-1 advantage in penalty corners.
Elizabeth Toft led the Owls (1-7, 0-4 CC) with 16 saves in goal.
Mele got McDaniel on the board early, converting off a penalty corner at the 6:21 mark.
Michelle Fluty (Huntingtown, Md./Calvert) made it 2-0 off her own rebound in the 18th minute.
Mandy Pickard (Hampstead, Md./North Carroll) found Mele for a 3-0 lead four minutes later before Jamie Smith (Pasadena, Md./Chesapeake) finished a Kelly McGarry (Ocean City, Md./Stephen Decatur) assist with 41 seconds remaining in the opening half.
Brooke Dixon (Clayton, Del./Smyrna) made it a one-goal, one-assist day, opening the five-goal second half just 57 seconds after the break.
Maggie Kirwan (Lambertville, N.J./George School), Heather Monaghan (East Fallowfield, Pa./Coatesville), Emma Ardolino (Freeland, Md./Hereford) and Kristina Skinner (Westminster, Md./Westminster) all scored their first goals of the season in the final 19 minutes.
Fluty added two assists while Monaghan, Kirwin and Skinner all added one assist.
The Green Terror returns to action at York (Pa.) on Tuesday. Game time is 4 p.m.
Score by Period 1 2 - F
McDaniel (5-4, 2-1 CC) 4 5 - 9
Bryn Mawr (1-7, 0-4 CC) 0 0 - 0
M – Kristin Mele (Brooke Dixon, Michelle Fluty), 6:21
M – Fluty, 17:24
M – Mele (Mandy Pickard), 21:29
M – Jamie Smith (Kelly McGarry), 34:19
M – Dixon (Lindsey McDonald, Kristina Skinner), 33:57
M – Maggie Kirwan (Fluty), 51:23
M – Heather Monaghan, 60:32
M – Emma Ardolino (Monaghan), 63:44
M – Skinner (Kriwan), 68:42
Shots: M 32, B 1. Penalty Corners: M 15, B 1. Saves: M 1 (Erika Wawzyanick 0, 0 GA, 35:00; Stephanie Thomson 1, 0 GA, 35:00), B 16 (Elizabeth Toft).